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Only when B12 injections became available was folate treatment abandoned, leaving many victims with irreversible B12-deficiency-related neurological damage
Crucially, FOXO4 knockdown significantly reduced the viability of senescent TM3 Leydig cells and substantially increased their rate of apoptosis
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However, the combined effects could theoretically impair beneficial swelling responses necessary for immune defense, though this has not been saw in research uses
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