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220 It has been suggested that finding a balance between limiting social participation (due to tinnitus discomfort) and spontaneously engaging in enjoyable activities is key to building tolerance

However, NLY01, a brain-penetrant, pegylated, longer-lasting version of exenatide, provided no significant benefits in PD patients with a H&Y stage of 2.5 and an average disease duration of 1 year, as assessed by the MDS-UPDRS Parts II and III scores

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These typically resolve within 7 to 14 days as steady state builds at the new dose