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Some individuals reduce the dose to the minimum effective level, while others maintain higher doses to prevent weight regain
Nat Clin Pract Endocrinol Metab (2005) 1:2231
The gap between trial and real-world tirzepatide vs semaglutide outcomes comes mostly from discontinuation and under-titration: only 25.9% of tirzepatide users reach 15 mg in practice, versus 83.5% of semaglutide users reaching 2.4 mg in the trial
It's not FDA-approved for any clinical use
Besides, the investigations indicate that although responses are variable, blood levels can be restored within only 1 week of supplementation, but it is unlikely that skeletal muscle levels are fully restored by the end of this period [22, 75]
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