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Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with MEN 2
Think with an additive mindset
The efficacy of the vial can be compromised by 20%, 50% or more due to one large temperature excursion
The PIONEER series (oral semaglutide) and SUSTAIN series (injectable semaglutide) provide evidence that injections consistently outperform tablets across weight loss, glycemic control, and cardiovascular outcomes in diabetes populations
GLP-1 receptor agonism is well established to slow gastric emptying, which can increase intra-gastric pressure and potentially promote acid reflux in susceptible individuals
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