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Semaglutide is one of several GLP-1 agonists approved for weight loss others are liraglutide (Saxenda) and tirzepatide (Zepbound)
The nucleotide sequence encoding mouse Ren1d was placed downstream of the liver-specific thyroxine-binding globulin (TBG) promoter and inserted into AAV8 vector to target the liver (46)
These could be mistaken for allergic reactions or make existing allergies feel worse
Clinical trials demonstrate significant reductions in hepatic steatosis with semaglutide and liraglutide, though fibrosis improvement remains modest
