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Y., Hu, J

A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II

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The 200 mg/kg dose showed the strongest protective effects, preventing glutathione depletion and tissue lipid peroxidation, with histological findings confirming minimal hepatic damage comparable to silymarin

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Admittedly, these metabolic analyses were focused on the initial phase of treatments, as this period displayed the largest changes in body weight and is less likely affected by compensatory responses, which might confound the identification of primary mechanisms