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Nausea is the single most common complaint, affecting a significant percentage of users especially during dose escalation
Allergic Reactions: Rare, but possible
One of the key trials, SUSTAIN 6, found that semaglutide lowered the risk of major cardiovascular events in high-risk patients with diabetes
Limit GLP-1 supply
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This is especially important when using GLP-1 agonists, which can cause lean mass loss alongside fat loss if exercise is not incorporated
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