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2) Engagement is linked to longer medication program persistence and stronger renewal In a separate January 2026 analysis focused on persistence, members in the top quartile of engagement were, on average, on a GLP-1 medication program for over twice as long (2.2x) within the first 12 months as those in the bottom quartile

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The results showed that retatrutide at the 8 mg dose reduced total body fat mass by 26.1% at 36 weeks, while the proportion of lean mass lost relative to total weight lost was consistent with other weight loss treatments

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