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Common side effects may include: Many side effects are mild and improve as your body adjusts

14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

Older age, male sex, HBeAg-negativity and high PAGE-B score were associated with lower pgRNA

Seek immediate medical attention if you experience severe, persistent abdominal pain (which may radiate to the back), with or without vomiting, as this could indicate acute pancreatitis, a rare but serious side effect of both incretin mimetics and DPP-4 inhibitors

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Gene modulation