tirzepatide attenuates mammary tumor progression in diet induced obese mice and cancer Highlighting 3 ongoing clinical trials of GLP-1 medications breast endometrial cancer Weight-loss drug Tirzepatide significantly slows

This research was funded by the National Natural Science Foundation of China, grant numbers 82374459 and Collaborative Medical Research Project of Traditional Chinese and Western Medicine at Zhongda Hospital, School of Medicine, Southeast University, grant numbers 2023zxyxt14

PMID: 8404634

Many patients experience substantial weight loss over 6-12 months, with an average reduction of 10-20% of their starting weight, depending on lifestyle habits and individual response to treatment

High blood sugar can lead to kidney damage over time

Together, our results suggest that exendin-4 induces adiponectin expression through the Sirt1/Foxo-1 signaling, and Foxo-1 functions as a transcription factor mediating the effect of exendin-4 on adiponectin expression

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