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Liver history, anemia, supplements, and copper exposure from other sources matter when interpreting results
Modulating NAD metabolism, histone modifiers (e.g., EZH2), or ATP-dependent chromatin remodelers (e.g., BRG1, CHD4) may shift the balance of repair pathway utilization, destabilize replication forks, or impair lesion recognition
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Thus, nutrients involved in one-carbon metabolism (folate, vitamin B12, vitamin B6, riboflavin) putatively affect epigenetic programming (100)
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