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Grading of the results The SoF table presents the grades for the certainty of the evidence supporting the primary outcome of the meta-analysis (Supplemental Table S2)
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Semaglutide is the first once-weekly medication in its class that may aid in long-term weight management, particularly when used in conjunction with a healthy diet and regular exercise
Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21
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