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For Novo Nordisk, this century-old grudge match was also personal

However, the authors urge caution in interpreting these findings due to the limited number of trials, the variations in study designs, and the heterogeneity in patient populations and substance types studied

Some clinicians recommend a microdosing approach to tirzepatide for patients who are particularly sensitive to side effects

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At the same time, some people with type 2 diabetes struggle less with weight management and have insulin resistance that is moderate enough that it can be managed by diet and lifestyle changes alone

Park et al., 2021)