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This multi-receptor mechanism distinguishes it from earlier weight-management medicines such as semaglutide (Wegovy) or tirzepatide (Mounjaro), and it also explains why gastrointestinal effects including changes to bowel habits are among the most frequently reported experiences in clinical trials

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You have the right to understand their rationale and feel comfortable with their explanation. Dr

The dual-agonist design was first characterized by Coskun and colleagues, who showed that a single peptide could engage both receptors with carefully tuned affinities (Coskun et al., Molecular Metabolism 2018