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Sufficient NAD+ availability is necessary for these enzymes to operate, so raising NAD+ levels could in theory modulate pathways related to aging, inflammation, and cell survival
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OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship
Acknowledgements This work was supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS, grant no
Weismann K, Jakobsen JP, Weismann JE, et al
The symptoms and the severity of the symptoms vary between individuals
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