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We further hypothesized that short-term dietary supplementation of two key amino acid precursors of GSH, glycine and cysteine, would increase intracellular GSH synthesis and concentrations and thus lower oxidative stress, despite continuing hyperglycemia

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The resulting O 2 oxidatively activates the epithelial MAPK/AP-1 pathway, promoting the release of IL-33 and TSLP

PubMed Ho, E.N., Kwok, W.H., Lau, M.Y., Wong, A.S., Wan, T.S., Lam, K.K., Schiff, P.J., Morishima, M., & Wong, C.H

It directly binds to oxidative compounds that damage cell membranes, DNA and energy production

Am J Hematol 93:363370 Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA et al (2014) Nonmyeloablative HLAmatched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype