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Energy and stamina both improved
The hypothesis is that glucagon-receptor agonism adds a thermogenic / increased-energy-expenditure component on top of the GLP-1R/GIPR appetite-and-insulin effects
Retatrutides triple-receptor approach (GLP-1 + GIP + glucagon) delivered 28.7% weight loss in Phase 3 and addresses energy expenditure in ways that neither Semaglutide, Cagrilintide, or even Tirzepatide can touch
doi: 10.3389/fnagi.2017.00118 8 SjholmBennetLNilssonPM
Dosing errors: Dosing errors have been reported with the use of compounded semaglutide since some of these alternative forms require patients to measure out their own doses
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