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Subgroup analyses evaluated four key factors: administration route efficacy, daily dosage, age group and clinical conditions that may affect vitamin B12 metabolism (e.g., underlying pathology)
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Aging reduces carnosine levels due to decreased carnosine synthase 1 (CARNS1) and increased carnosinase 2 (CNDP2) activity, impairing its protective capacity in ECs [179]
Formula: Desired concentration = Total mg of compound Total ml of BAC added Example: 5 mg compound + 2 ml BAC = 2.5 mg/ml
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