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Unlike Ozempic, which works through GLP-1 alone, retatrutide adds GIP and glucagon receptor activity on top of the GLP-1 backbone
Tirzepatide for Obesity Management We analyzed 12 randomized trials comparing two leading incretin-based therapies: Weight Reduction Retatrutide: 16.3 kg | 23.8% Tirzepatide: 11.8 kg | 16.8% Retatrutide demonstrated greater efficacy in both absolute and percentage weight loss
Given as a single agent, it promotes modest increases in survival, and these effects are enhanced when combined with oxaliplatin and/or irinotecan (FOLFOX, FOLFIRI) 2,3
It reduces appetite, improves insulin secretion, and increases energy expenditure through multi-hormonal receptor activation
