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In this context, it is believed that the use of GLP-1 receptor agonists (GLP1-RA) associated with lifestyle intervention already in the early stage of the disease may help prevent the progression of -cell dysfunction, thanks to the action of these drugs on body weight and probably their direct effect on -cells [50]
doi:10.1016/B978-044452763-9/50052-4
Mechanisms Methods 30 (6), 397406
Preclinical studies in diet-induced obese (DIO) mice showed that once-weekly administration of the PEGylated GLP-1R/GcgR co-agonist for 1 month dramatically lowered body weight, compared with vehicle treatment [17]
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