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Gastrointestinal side effects represent the most commonly reported adverse events with tirzepatide therapy, occurring in a substantial proportion of patients during clinical trials

Warning signs that need medical attention Seek medical evaluation within 24 to 48 hours if you experience: Redness that continues expanding beyond 48 hours after injection Redness diameter exceeding 10 centimeters Increasing pain (not decreasing) after 48 hours Warmth and hardness accompanied by fever above 100.4 F (38 C) Pus, drainage, or fluid oozing from the injection site Red streaks extending outward from the injection site (sign of lymphangitis) Reaction that has not shown any improvement after 7 days Seek emergency medical care immediately if you experience: Hives or rash spreading beyond the injection site to other body areas Swelling of the face, lips, tongue, or throat Difficulty breathing, wheezing, or shortness of breath Dizziness, lightheadedness, or feeling faint Rapid heartbeat Severe abdominal pain These emergency symptoms suggest a systemic allergic reaction (anaphylaxis), which is rare but documented with tirzepatide

GLP-1 receptor agonists are among the most clinically significant drugs to reach mainstream use in a generation

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"The HCSC transaction closed later than the company's financial planning assumptions, increasing the first quarter Cigna Healthcare [MLR] as the Medicare businesses operate at a higher [MLR] compared to the rest of the portfolio," the company wrote in its filing

People with a history of kidney stones should be cautious because gelatin can increase urinary oxalate excretion in sensitive individuals