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In addition to the lower incidence of nonfatal stroke in clinical trials [22, 40, 57], treatment with liraglutide or semaglutide (sc or oral) decreased the risk of dementia by 53% compared to the risk associated with placebo (HR 0.47, 95% CI 0.250.86) according to a pooled post hoc analysis of the LEADER, SUSTAIN 6 and PIONEER 6 trials, including 15,820 patients with T2DM [65]
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A gradual, personalized dosing schedule is crucial for comfort, safety, and results
NICE recommends individualised diet support and physical activity goals, while the NHS advises adults to include strengthening activity at least twice weekly
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