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Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)
10.1111/tpj.12016 157 TimmermanK
In all closed-state KAR structures, apo or competitive antagonist-bound, the pore geometry in this region is strikingly similar, with the pore radii smaller than the diameter of a water molecule (Figure 7F)
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Tumor-associated macrophages (TAMs), important immunosuppressive cells in the microenvironment, are able to activate the Gli2/IGF-2/ERK1/2 signaling axis to promote TGF- secretion and thus mediate the migration, invasion and EMT of hepatocellular carcinoma cells (Huh-7 cells) (73)
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