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GLP-1RAs and muscle GLP-1RAs and Muscle Atrophy In previous experiments, exendin-4 (Ex-4) inhibited the expression of myostatin (MSTN), atrophy-factor F-box only protein 32 (atrogin-1) and muscle ring finger protein 1 (MuRF-1) in dexamethasone-treated C2C12 myotubes
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In direct cell-cell contact and indirect mechanisms, tumour cells induce nonmalignant cells, such as fibroblasts, endothelial cells, and immune cells, to migrate to the TME [185]
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For years, GIP was considered less important for glucose control than GLP-1 because patients with type 2 diabetes often show reduced GIP responsiveness
It is now available under a Creative Commons Attribution 4.0 International license, CC-BY, The Author(s)
