constipation from glp 1 GLP‑1 and constipation: why it happens and how to find relief Constipation & Weight Loss Medications

The most frequently reported issues: Nausea Vomiting Constipation Diarrhea Acid reflux Reduced sensation of thirst, which can worsen constipation if patients arent actively drinking enough water Janey Pratt, MD, a clinical professor of surgery at Stanford Medicine who performs bariatric surgery on adolescents at Lucile Packard Childrens Hospital Stanford, said nearly all her young patients have some degree of side effects

When these molecules outnumber antioxidants, the body enters a state of oxidative stress

Transitioning from weight loss to maintenance Determining goal weight achievement: Lost 10-12% body weight (cagrilintide alone) Lost 15-25% body weight (CagriSema) Weight stable for 4-8 weeks Satisfied with current weight Ready to focus on maintenance Maintenance dose options comparison: Option 1: Continue same dose Keep cagrilintide at 2.4mg weekly Ensures no regain Most conservative approach Highest cost Option 2: Reduce dose slightly Decrease to 1.8-2.0mg weekly Monitor weight for 4 weeks If stable, maintain If gaining, increase back 20-25% cost savings Option 3: Try every 10 days Instead of weekly, inject every 10 days Effectively 30% dose reduction Some maintain weight this way Requires close monitoring Recommendation: Try Option 2 first (reduce to 1.8-2.0mg)

This ensures the maintenance of high levels of these antioxidants

Early-stage weight stagnation is expected

[19] Because of its antioxidant role, GSS mostly produce GSH inside the cytoplasm of liver cells and imported to mitochondria where detoxification occurs