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Emerging preclinical and clinical evidence suggests that GIPR agonism can play a role in reducing the GI AEs of GLP-1R agonism and enable greater therapeutic potential

We reported that liver-specific TGF-/SMAD4 knockout mice develop hemochromatosis through hepcidin loss and increased iron absorption-a model for ferroptosis ( Cell Metab

Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons

Conclusion A new drug named tirzepatide has been approved to treat T2DM, and it is expected to be approved for weight loss by activating both GLP-1 and GIP receptors through a unique mechanism