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Autophagy promotes ferroptosis by degradation of ferritin

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Death from hepatic injury usually occurs 35 days post-ingestion

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As expected, with time or with increase of H 2 O 2 concentration, the protein levels of progerin, p53, and p21 in primary rat hepatocytes showed a concentration-dependent and a time-dependent upregulation of progerin expression and activation of the p53/p21 pathway, as a result of oxidative stress (Supplementary Fig