ER and Golgi apparatus were stained using ER-Tracker Red (Fisher Scientific 11584746) diluted 1:2000 and anti-Giantin (BioLegend 908701) 135 diluted 1:500
The most robust evidence to date comes from the phase 2 randomised controlled trial (Jastreboff et al., NEJM , 2023)
Health Canada's bioequivalence standard requires the generic to release the same amount of active ingredient into the bloodstream at the same rate as the brand
While drug regulators and manufacturers are responsible for ensuring safety and putting safeguards in place to prevent misuse, neither responded to TNIEs queries on their preparedness to ensure quality, robust supply chain measures, and ethical use.
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