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3 Preclinical evidence of neuroprotective effects of GLP-1R agonists in DPN In patients with DM, the metabolism of glucose, lipids, proteins, and nuclear acids is largely dysregulated
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Previous human trials have shown that subcutaneous administration of oxyntomodulin three times daily for 4 weeks resulted in 1.8 kg greater weight loss than controls [44] as a result of increased activity-related energy expenditure (143 kcal/day) and decreased energy intake (128 kcal) [45]
Most patients begin experiencing weight loss within the first two weeks following their first treatment
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The survival probabilities derived from the results (i.e., hazard ratios [HRs]) of multivariable Cox proportional hazard model analyses with adjustment for imbalanced patient characteristics were used to estimate the NNT measures (Eq
