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Injection site reactions, unusual fatigue , dizziness , and gastrointestinal symptoms beyond what the drug typically causes could indicate contamination

Additionally, the increase in microvascular blood flow in muscles contributes to reduced intramuscular fat accumulation and alleviation of myosteatosis, while AMPK pathway-mediated increased fat oxidation supports the mobilization of intramuscular fat, allowing for improvements in energy metabolism and reduction of fat within muscle tissue [39]

Medical writing support, under the direction of the authors, was provided by Eric Comeau, Ph.D., of CMC Connect, McCann Health Medical Communications and was funded by Pfizer Inc., New York, NY, USA, in accordance with Good Publication Practice (GPP3) guidelines (Ann Intern Med 2015;163:461464).

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Generally, tirzepatide is well tolerated