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In isolation, the catabolic and thermogenic actions of glucagon would be beneficial to individuals who are obese or have type 2 diabetes but these actions are inherently paired with the undesirable stimulation of gluconeogenesis and glycogenolysis

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The peptide also improved healing of colonic anastomoses and reduced adhesion formation in surgical models 7

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88 found that while VSG was associated with lower fracture risk than malabsorptive procedures such as RYGB, it still conferred a modestly elevated risk compared to non-surgical controls (OR = 1.23, 95% CI: 1.051.44)

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It may also spare amino acids from being used as fuel, leaving them available for repairing and building new muscle tissue

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