Reducing application frequency or concentration can minimize irritation for sensitive individuals
Common Side Effects Pain or redness at the injection site Mild nausea Headache Dizziness Mild skin rash Serious and Rare Side Effects Severe allergic reactions Swelling of the face, lips, or throat Difficulty breathing Severe skin reactions Persistent or worsening symptoms requiring immediate medical attention Most side effects are mild and temporary
The right form depends on the patients health needs and therapy type
Although GHK-Cu and Pal-GHK are widely used in anti-wrinkle products available on the cosmetic market, the published information on their skin permeability, effectiveness, physicochemical properties and so on is insufficient
GHK-Cu, a naturally occurring copper-binding peptide, primarily targets skin rejuvenation and wound healing through collagen stimulation (Pickart et al., Journal of Cosmetic Dermatology, 2018)
A final alternative to alleviate FcRn-controlled pathological mechanisms could be to alter FcRn in itself, as may be intended with a gene therapy being developed in a collaboration between Beam and Apellis for a one-time dose of gene-editing molecules targeting FcRn [436, 437]