In db/db mice, exendin-4 (EX-4) significantly suppressed the overexpression of pyroptosis-related proteinsincluding ASC, caspase-1, IL-1, and GSDMD
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weight management for specific formulations like Saxenda and Wegovy) Healthcare professionals should remain vigilant for signs of pancreatitis, which is listed as a known adverse effect in the Summary of Product Characteristics (SmPC) for all GLP-1 agents There is no official link established between GLP-1 therapy and pancreatic cancer based on current evidence NICE guidance for type 2 diabetes management (NG28) continues to recommend GLP-1 receptor agonists as appropriate treatment options when specific criteria are met
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Risks listed by the department The advisory enumerates specific risks associated with unauthorized or counterfeit products, including: containing too much, too little, or none of the active ingredient containing unlisted, dangerous or unknown ingredients containing contaminants such as solvents, heavy metals, particles, or microbials being poorly or incorrectly labelled, or improperly manufactured or stored Health Canada adds that unauthorized injectable products carry additional risks such as infections due to lack of sterility, allergic reactions, and other serious negative outcomes due to contamination, improper handling, or unsafe administration