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In a mouse model of hepatocellular carcinoma induced by diethylnitrosamine (DEN), liver GCN5L1 knockout increased DEN sensitivity in the model

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Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72

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They are associated with oxidative stress, even though the causes differ

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