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It can occur spontaneously, after prior radiation exposure, or from transformation of benign plexiform neurofibromas, especially in people with Neurofibromatosis type 1 (NF1)

Due to its potent dual-incretin action, tirzepatide regularly drives HbA1c reductions exceeding 2.0% in clinical cohorts, with a substantial percentage of participants achieving complete normalization of blood glucose profiles (HbA1c below 5.7%) without increasing the risk of hypoglycemia

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