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Telomere shortening is one hallmark of aging among many (genomic instability, epigenetic drift, mitochondrial dysfunction, cellular senescence, loss of proteostasis, stem-cell exhaustion, and others), and the relationship between telomere length, telomerase activity, healthspan, and cancer risk is complex and bidirectional in several mammalian settings, more telomerase means more, not less, cancer
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The NPALN/Mn-AP system described earlier utilizes alendronate functionalization to achieve bone-targeted delivery of ATM and PRMT5 inhibitors along with Mn ions for cGAS-STING activation (21)
Additional Resources: Gaby, A
University of Oxford
Candidatus Helicobacter heilmannii from a cynomolgus monkey induces gastric mucosa-associated lymphoid tissue lymphomas in C57BL/6 mice
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