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The short-acting GLP-1 receptor agonists primarily lower postprandial blood glucose levels through inhibition of gastric emptying, whereas the long-acting compounds have a stronger effect on fasting glucose levels, which is mediated predominantly through their insulinotropic and glucagonostatic actions

However, in approximately 510% of patients, digestive side effects are severe enough to warrant dose reduction or discontinuation of treatment

Additionally, thyroid hormones were reported to affect spermatogenesis, Leydig, and Sertoli cells

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The consistent finding across this body of work: no evidence of carcinogenic potential