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This review has several limitations

The clinical applications of semaglutide have expanded beyond diabetes to include the treatment of obesity in individuals without diabetes

White patients are more likely to use online weight-loss clinics, while Black and Hispanic patients more often rely on in-person care, particularly primary care physicians

Staying at a lower dose longer

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AOD-9604, despite a safety database spanning six trials and around 900 participants, saw its early positive efficacy signal fail to replicate in its largest confirmatory trial meaning its safety data is well established