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The incretins have far stronger and more mature human clinical data
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Its clinical program in the 1990s in Croatia (intended for approval for Crohns disease, an autoimmune inflammatory bowel disease) stopped at Phase 2
Angiogenic support encourages small vessel growth, which brings nutrients to areas that often lag behind circulation
For example, the general applications of adeno-associated virus-based gene therapy are hampered by pre-existing humoral immune responses against the viral vectors [350,351,352], which for some viral serotypes occur in up to 60% of the population because of early-life infections [353, 354]
This effect has been linked to enhanced NO bioavailability and the upregulation of p-eNOS and HO-1 expression
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