10.1016/S0140-6736(21)02188-7 7 DubskyM.VelebaJ.SojakovaD.MarhefkovaN.FejfarovaV.JudeE
Study period 1/1/2017 to 7/1/2025 Study population: inclusion Patients with A GLP-1 prescription for at least 90 days At least five pounds of weight loss while on the GLP-1 A weight reading between 30 days prior through 3 days after starting the GLP-1 A weight reading within 30 days of stopping the GLP-1 At least one weight reading 1 to 24 months following end of the GLP-1 Study population: exclusion Thyroid conditions (ever): ICD-10-CM E03*or E05* Eating disorders (ever): ICD-10-CM F50* Pregnancy within a year before GLP-1 start through GLP-1 stop Censoring Other weight loss medication or restart of GLP-1 Amputation Bariatric surgery Pregnancy that started in period after GLP-1 was stopped Outcomes Percent of weight change relative to initial weight loss after end of GLP-1 treatment GLP-1 A medication with a simple generic of semaglutide, liraglutide, or tirzepatide

The GLP-1s tirzepatide and semaglutide were in shortage from 2022 until October 2024 and until February 2025, respectively
Patients should be counseled that these medications are not recommended during pregnancy or lactation
By understanding their individual benefits and potential synergies, individuals can make informed choices that align with their health goals
It is vegan-friendly and highly absorbable, free from hormones, sulfates, and common allergens, and contains no heavy metals, mineral oil, or carcinogenic sunscreen ingredients