4,7 The link between hearing loss and tinnitus has been suggested to be due to a compensatory effect: the brain compensates for decreased activation of the auditory nerve (which carries signals from the cochlea to the brain) by increasing gain or signal amplification in the auditory system of the brain, as well as decreasing auditory signal inhibition, which may result in tinnitus and possibly hypersensitivity to noise
We believe this is the first demonstration of a synergistic combination between a E3 ligase inhibitor and a deubiquitinase inhibitor, cementing the promise of the ubiquitin system as a potential therapeutic target in oncology research
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These are powerful tools that must be deployed strategically, not indiscriminately