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High-dose niacin therapy is normally contraindicated in individuals with active peptic ulcer disease or active liver disease
Claimed outcome NAD+ changes Evidence level Cell and animal evidence What research currently shows Blocking NNMT can preserve nicotinamide, a building block used to make NAD+
these effects are generally dosedependent
Preclinical data and clinical observations point to potential in chronic inflammatory conditions (like IBD) , persistent joint injuries, and even neuroprotective support
Some people look for localized use near an injured tendon in the belief that it may provide more targeted effects
However, those with a higher risk of not getting enough B12 are vegetarians and vegans, as they get little to no B12 from their diet
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