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FDA and the National Library of Medicine highlights the same concerns: dependency, high cost, and side effects such as nausea or digestive discomfort

Subcutaneous Self Injections: Subcutaneous Self Injections Are there any side effects

doi: 10.1016/0016-5085(86)90936-4 Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

It isn't approved for treating obesity, but during tirzepatide diabetes trials, researchers noted people who got tirzepatide lost much more weight than those on standard diabetes therapy

Constipation, diarrhea, and general digestive discomfort can make the weight loss journey more difficult than necessary

Importantly, GLP-1 agonists also have been shown to have protective effects in the brain