Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)
Beneficial effects of bovine milk exosomes in metabolic interorgan cross-talk
Compromised Detoxification The liver uses glutathione extensively for detoxification processes, specifically in phase II of liver detox, where harmful substances like heavy metals, environmental toxins, and metabolic waste products are made more water-soluble for easier elimination
Quantitative real-time imaging of glutathione with subcellular resolution
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
Occasionally, symptoms such as loss of appetite, nausea, vomiting, and epigastric pain may occur