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These include agents based on peptide YY (PYY), CCK, melanocortins, leptin, and GLP-1 as well as small molecule anorectics (phentermine/sibutramine) (54, 118123)

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Retatrutide is also being studied in additional trials, including a direct comparison with tirzepatide and a large cardiovascular and kidney outcomes study

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Lab work isnt consistently required, and some users are approved based purely on their questionnaire responses

Alexis Pedrick: This led to congressional hearings, which compelled the FDA to act