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Indeed, it is evident that high concentrations of Vitamin B12 are an essential component of a healthy and active lifestyle

10.1016/j.orcp.2021.02.002 45 RothM.OrijaI

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While there are several types of these receptors, like VEGFR-1, VEGFR-2, and VEGFR-3, it appears that the primary mediator of angiogenic response is most likely VEGFR-2

Low B12 doesnt directly cause weight gain, but chronic fatigue and slow metabolism from a deficiency may lead to reduced activity levels, contributing to weight gain over time