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A great deal of GLP-1 signaling happens through the nervous system L-cells activate sensory neurons in the gut wall, and GLP-1 receptors in the brain govern satiety

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"Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin," according to the aforementioned researchers

Safary M, Hakimi S, Mobaraki-Asl N, Amiri P, Tvassoli H, Delazar A