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To avoid intestinal degradation and diarrhea, pharmaceutical companies sought to develop an oral SGLTi to specifically target renal glucose reabsorption
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181 Further, the activity of G6PD is also repressed by aspirin casing acetylation of G6PD to decrease the activity of G6PD and the generation of NADPH, and by RRx-001, a novel clinical-stage chemosensitizer and radiosensitizer, which exerts antiproliferative effects in human tumor cells
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