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These variations are concentrated in genes related to protein synthesis, mitochondrial function, and virulence factors like HSP78 and sterol 24-C-methyltransferase, along with CNVs affecting mitochondrial transport, vesicular trafficking, and protein turnover (Shaw et al., 2019
L.BaggerlyC
PMID 18990082
Collectively, our results indicate that balancing mechanisms to ensure proper DUB turnover may be more widespread than previously recognized
Consider that IV achieves 90-100% bioavailability but requires clinical visits and carries anaphylaxis risk
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