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In an inflammatory setting induced by IL-1, increased levels of hypoxia-inducible factor-2 (HIF-2) coupled with diminished GPX4 expression in chondrocytes increase their susceptibility to ferroptosis ( Figure 4 ) (80, 161)

Acknowledgements The authors would like to acknowledge and thank Nadia Everaert and Yong Zhao for their help editing this manuscript

Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age

Before Wegovy tablets can be offered in the UK, they must first be approved by the Medicines and Healthcare Regulatory Agency (MHRA)